Göke Lab

Computational Genomics and Transcriptomics @ GIS

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How can different cell types arise from the same genome? What discriminates a normal cell from a cancer cell? Will genomics data help to understand, model, and predict human disease progression?

Welcome to the website of Jonathan Göke’s team at the Genome Institute of Singapore!

We’re a computational genomics group searching for answers to these questions. We develop algorithms and investigate genomics and transcriptomics data to study cellular identity and the origin of human diseases. Our group specifically works on third generation sequencing technology. We are located at the Genome Institute of Singapore. Read more about us, our research and publications, or available scholarships (PhD, internships) and positions. You can find more information about methods from the team on our github page.

Recent lab news

28/07/2020: Congratulations Chen Ying for reeiving the Best Talk award in HiTSeq/ISMB 2020! Chen Ying presented about her method, bambu, for transcript discovery and quantification using Nanopore long read RNA-Seq data (https://github.com/GoekeLab/bambu)

26/06/2020:New Preprint from Ploy Pratanwanich about her method that enables the analysis of differential RNA modifications using direct RNA-Seq data: https://www.biorxiv.org/content/10.1101/2020.06.18.160010v1.full  xPore is available through github page: https://github.com/GoekeLab/xpore you can read the documentation here

18/06/2020: Chen Ying and Ploy Pratanwanich will present their work on RNA modifications and transcript quantification at London Calling 2020. You can test their software on out github page: https://github.com/GoekeLab

26/03/2020: The DREAM Challenge paper on multiple myeloma risk prediction is published (you can read it here). Congratulations again to Christine and Jiayi from our group for winning this challenge and contributing the best performing predictor!

05/02/2020: The Pan Cancer Analysis of Whole Genomes (PCAWG) is published! Congratulations to everyone involved from our group, GIS and all international collaborators (see publications)

Nature_PCAWG

31/01/2020: Congratulations for winning the Genome Institute of Singapore graduate student prize Deniz!Deniz_graduateStudentPrize

13/01/2020: Deniz has prepared detailed supplementary tables for his manuscript (Demircioglu et al. (2019)). You can find the additional information here

05/11/2019: Jonathan presents at the Frontiers in Cancer Science meeting in Singapore

05/09/2019: Our first paper is published on the cover of Cell! Congratulations to the first author Deniz Demircioglu and everyone else who has contributed! You can read the article here.Cell Cover 2019

01/07/2019: Postdoctoral positions are available for computational postdocs to work on long read direct RNA-Sequencing, you can contact Jonathan for more details.

28/2/2019: You can watch a webinar about the Singapore Nanopore-Expression project today

15/2/2019: Happy Chinese New Year! Some updates to the team site and new pictures from this year’s Lo Hei

Find more news in our News Archive.