Göke Lab

Computational Genomics and Transcriptomics @ GIS


How can different cell types arise from the same genome? What discriminates a normal cell from a cancer cell? Will genomics data help to understand, model, and predict human disease progression? What are retrotransposons, and how do they influence our cells?

Welcome to the website of Jonathan Göke’s team at the Genome Institute of Singapore!

We’re a computational genomics group searching for answers to these questions. We develop algorithms and investigate genomics and transcriptomics data to study cellular identity and the origin of human diseases. Our group specifically works on third generation sequencing technology. We are located at the Genome Institute of Singapore. Read more about us, our research and publications, or available scholarships (PhD, internships) and positions.

Recent lab news

15/2/2019: Happy Chinese New Year! Some updates to the team site and new pictures from this year’s Lo Hei

1/1/2019: Happy New Year from the Göke lab! Some updates coming soon…

29/11/2018: Jonathan will present data from the Singapore Nanopore-Expression Consortium (SG-NEx) at the Nanopore Community Meeting in San Francisco

16/09/2018: 3 new lab members joined us in August and September: Welcome Naruemon Pratanwanich (Ploy), Chen Ying, and Christopher Hendra!

10/09/2018: Jonathan gives a talk about Precision Medicine and Genomics Technologies in Singapore at the Data Science in Health Symposium, Marina Bay Sands Expo & Convention Centre

24/06/2018: New publication from the Göke lab in collaboration with Azims Surani and Chris Smith in Cambridge: SRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements.

16/03/2018: Jonathan present at the Global Young Investigator Forum 2018 in Nagoya, Japan

14/03/2018: Jonathan will present 2 workshops on analysing ChIP-Seq data, RNA-Seq data, and experimental design at Nagoya University

10/01/2018: New postdoc position available! Have a look in the postdoc section and feel free to write to Jonathan for more information.

14/12/2017: Our team ranked top in the Dream Multiple Myeloma Risk Prediction machine learning challenge! Congratulations to Christine Eng and Jiayi Bao!
07/11/2017: Jonathan presents at the EMBL Cancer Genomics meeting in Heidelberg
13/09/2017: Jonathan will give a talk in the Computational Biology lunchtime seminar at DUKE-NUS today, 12-1pm
16/08/2017: The lab’s first biorxiv preprint is posted online: A pan cancer analysis of promoter activity highlights the regulatory role of alternative transcription start sites and their association with noncoding mutations
31/07/2017: Christine Eng joined our group to work on machine learning using genomics and clinical data. Welcome Christine!
24/07/2017: Deniz Demircioglu from our group presents his work on promoters in cancer at ISMB 2017 in Prague. Congratulations Deniz!
09/05/2017: Jonathan will present about the group’s work on promoters in cancer at the CSH Biology of Genomes meeting.
20/04/2017: Martin Kindermans joined our group in March. Welcome!
06/03/2017: “Introduction to Genomics” guest lecture by Jonathan for the Data Science program at NUS, 12-14h, Statistics Department

Find more news in our News Archive.